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Complex fibroadenoma- Key Features
Histopathology

Complex fibroadenoma- Key Features

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Histology of fibroadenomas include the following features:

  • Two growth patterns are predominantly identified in classic fibroadenomas. These patterns do not carry much clinical significance.
    • Intracanalicular: glands are compressed into linear branching structures by proliferating stroma
    • Pericanalicular: glands retain open lumens but are separated by expanded stroma
  • Glandular elements have intact myoepithelial cell layer

Complex fibroadenomas are a subtype of fibroadenomas with additional histologic features that can include:

1. Sclerosing Adenosis: Proliferation of acini with fibrosis.


2. Epithelial Calcifications: Calcium deposits within the epithelial cells.


3. Papillary Apocrine Changes: Papillary projections with apocrine metaplasia.


4. Cystic Changes: Formation of cysts within the fibroadenoma.

Usually has a peri-canalicular growth pattern.


Has increased relative risk of progression to breast carcinoma when compared to other variants of fibroadenoma.

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Reference: WHO 5th edition breast tumors- 2022

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