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IMPORTANT TRANSLOCATIONS IN LYMPHOMAS AND LEUKEMIAS
General Pathology

IMPORTANT TRANSLOCATIONS IN LYMPHOMAS AND LEUKEMIAS

pathologymcqs1 min read
Burkitt lymphomaFollicular lymphomaGeneticsGenetics in lymphomas and leukemiasHematopathologyLeukemiasLymphomasMALT LymphomaMantle cell lymphomapathologyTranslocations in leukemias and lymphomas

Certain lymphomas and leukemias have a very specific genetic translocations.

It is not only important for diagnostic purposes, but also for treatment. Here are a few very important ones medical students must know.

1. Acute lymphocytic leukemia (ALL)- t(12;21)

2. Acute myeloid leukemia (AML)

a) t(8;21) - fusion of RUNX-RUNX1
b) t(15;17) - fusion of PML-RARA
c) inv (3)

3. Chronic myeloid leukemia- t(9;22) results in BCR-ABL fusion gene.

4. Burkitt lymphoma- Most common translocation in Burkitt lymphoma is t(8;14)

5. Follicular lymphoma- t(14;18)

6. Mantle cell lymphoma - t(11;14)

7. MALT- lymphoma - t(11;18)

Genetic translocations in lymphomas and leukemias. Most important translocation in AcuTE LYMPHOCYTIC leukemia t(12;21). Translocations in acute myeloid leukemia are t(8;21), t(15;17); inv(3). Burkitt lymphoma- t(8;14). Mantle cell lymphoma- t(11;14). Follicular lymphoma- t(14;18).
Genetic translocations in lymphomas and leukemias

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